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・ Geranyl pyrophosphate
・ Geranyl-diphosphate diphosphate-lyase
・ Geranyl-diphosphate diphosphohydrolase
・ Geranyl-pyrophosphate—olivetolic acid geranyltransferase
・ Geranylfarnesyl diphosphate synthase
・ Geranylfarnesyl pyrophosphate
・ Geranylgeraniol
・ Geranylgeraniol 18-hydroxylase
・ Geranylgeranyl diphosphate diphosphatase
・ Geranylgeranyl diphosphate reductase
・ Geranylgeranyl pyrophosphate
・ Geranylgeranyl-diphosphate diphosphohydrolase
・ Geranylgeranyl-diphosphate geranylgeranyltransferase
・ Geranylgeranylation
・ Geranylgeranylglycerol-phosphate geranylgeranyltransferase
Geranylgeranyltransferase type 1
・ Geranylhydroquinone 3''-hydroxylase
・ Geranyltranstransferase
・ Gerar
・ Gerar Jarso
・ Gerarai
・ Gerarca
・ Gerarchia
・ Gerarctia
・ Gerard
・ Gerard & Jacques
・ Gerard 't Hooft
・ Gerard (Aboriginal Council)
・ Gerard (album)
・ Gerard (archbishop of York)


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Geranylgeranyltransferase type 1 : ウィキペディア英語版
Geranylgeranyltransferase type 1

Geranylgeranyltransferase type 1 or simply geranylgeranyltransferase is one of the three enzymes in the prenyltransferase group. In specific terms, Geranylgeranyltransferase (GGTase 1) adds a 20-carbon isoprenoid called a geranylgeranyl group to proteins bearing a CaaX motif: a four-amino acid sequence at the carboxyl terminal of a protein. Geranylgeranyltransferase inhibitors are being investigated as anti-cancer agents.
== Function ==

Prenyltransferases, including geranylgeranyltransferase, posttranslationally modify proteins by adding an isoprenoid lipid called a prenyl group to the carboxyl terminus of the target protein. This process, called prenylation, causes prenylated proteins to become membrane-associated due to the hydophobic nature of the prenyl group. Most prenylated proteins are involved in cellular signaling, wherein membrane association is critical for function.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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